General

• Resource-constrained areas
• Clinical Evidence/Trials
• Cost Effectiveness to expand RT indications
• Value-Based Care
• Operational Studies (reducing infrastructure complexities, reducing clinician burden)

Adaptive radiotherapy

• Treatment quality (clinically meaningful metrics), compare to historical
• Outcome modeling (NCTP, TCP, etc.)
• Automated target contouring
• Deformable image registration and/or dose accumulation
• Longitudinal response assessment
• Novel approaches pushing the therapeutic envelope (shrinking margins, increasing tumor doses)
• Functional adaptation (multi-modality imaging applications using adaptive tools)
• Novel use of adaptive tools

Artificial intelligence

• Increasing safety of systems and processes
• Error detection and augmentation (treatment planning, data transfer, imaging, treatment delivery)
• Decreasing planning and treatment variability
• Uncertainty quantification
• Assisted plan review
• Novel algorithms, benefits and applications
• AI agents
• Reinforcement, continuous or incremental or transfer learning
• Clinical benefits
• Outcomes prediction

Cancer care management

• AI-based workflow optimization
• Patient Reported Outcomes and impact on care
• Elevating patient engagement
• AI-based scheduling and resource utilization
• Survivorship focused research
• Elevating outcomes using digital technology

Clinical operations

• Analysis of care patterns, efficiency studies, etc
• Quantifying benefits of software tools
• Centralized treatment planning

Clinical studies

• Use and value of new Varian technologies and solutions (e.g. Hypersight, RapidArc Dynamic, Ethos, etc.)
• Evaluation and clinical evidence generation on novel applications and radiation using linear accelerators for non-oncologic
• Use of SBRT, especially for oligometastatic disease
• Use of various SFRT to expand the indication
• Health Economic and cost effectiveness studies (e.g., RT vs non-RT modalities)
• Clinical studies in precision medicine, incorporating genomic and/or radiomic information into Varian systems
• Evaluation of novel applications of radiation using linear accelerators for non- oncologic diseases (functional SRS, pain, OCD, etc)

Imaging

• Technology comparison of imaging techniques for specific applications
• Unique multi-modal imaging applications
• Site-specific imaging solutions for unmet clinical needs
• Incorporating imaging with dynamic trajectories during

Motion management

• DTS for motion monitoring during treatment
• Soft tissue tracking/monitoring during treatment delivery
• Unique methods for noninvasive internal motion monitoring
• Respiratory regulation techniques/studies
• Optimal breath-hold approaches

Automation

• Target segmentation
• Identification of crucial inputs
• Evidence-based decision making